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Key Points Ipamorelin stimulates growth hormone release by mimicking growth hormone releasing hormone (GHRH), while Ibutamoren acts by mimicking ghrelin

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Patients should also tell surgical and anesthesia teams about GLP-1 or tirzepatide treatment before procedures involving general anesthesia or deep sedation because current labeling includes warnings related to delayed gastric emptying and pulmonary aspiration

Importantly, this concept does not imply overt NAD depletion

However, stratification by sex showed a significant reduction in out-of-hospital cardiac arrest risk for women which may be related to the weight loss effect of GLP-1RAs [34]