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Unlike many types of cells, pancreatic beta cells express very low levels of lactate dehydrogenase (LDH) [17] and do not regenerate NAD + via lactate formation

doi: 10.1016/j.cell.2020.09.033 46 CoricV.MilosevicI.DjukicT.BukumiricZ.Savic-RadojevicA.MaticM.et al

To restore NAD + levels, ATM-deficient models were treated with NR, which stimulated PINK1-dependent mitophagy, reduced cytoplasmic DNA levels, and activated the NAD + -dependent SIRT1 signaling pathway, which in turn further promoted mitochondrial mitophagy and healthy morphology 111,288

While nitrate (NO) itself is relatively inert and does not directly cause oxidative or nitrosative stress, it is considered an important storage and endproduct of nitrogen-based redox reactions

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