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Accessed 1 Feb 2022 Shahab L et al, A comparison of exposure to carcinogens among roll-your-own and factory-made cigarette smokers

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They found that in 75 cohorts (total 24 million participants) that adjusted for cardiovascular risk factors other than coronary heart disease, the pooled adjusted female-to-male relative risk ratio (RRR) of smoking compared with not smoking for coronary heart disease was 125 (ie, 25% higher for women)