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These parameters act through distinct yet interconnected pathways to disrupt the delicate orchestration of the circadian system, with downstream consequences for reproductive endocrinology (Figure 3)

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These researchers also posit that the involvement of MC5 receptors in certain peripheral glands may potentially provide a parallel route that links central neuro signaling with peripheral modulatory factors

Choline, a vital amine. Science 5378 (1998): 794-795