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The signature Fresh-Loc resealable packaging keeps the tobacco fresh, making it a favorite among pipe smokers and RYO enthusiasts alike

The type of e-cigarette interventions (nicotine content, whether NRT was also given, nicotine cartridge vs e-liquid, and whether behavioral support was also provided) and control interventions (NRT vs nonnicotine e-cigarette) varied across studies, making comparisons difficult

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A systematic review published in Clinical and Experimental Dental Research found clear evidence in a 2023 systematic review published in Clinical and Experimental Dental Research that tobacco exposure deeply stains dental hard tissues and composite restorative materials