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Chronic inflammation induced by cigarette smoke exposure releases various inflammatory components, including the cytokines, TNF-, IL-1 and IL-6, and the chemokines, CXCL1 and CXCL8

The few tobacco-flavored products currently authorized by the FDA are deeply unpopular

Fatigue : A lack of nicotine can make the body feel more tired and sluggish, particularly during the first few days of withdrawal

Which means that each person is inhaling far less smoke by volume than they would smoking one bowl by themselves

Users may engage in risky activities they would typically avoid, increasing the chances of accidents, violent encounters, or other dangerous situations