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In our study, data revealed that the plasma and urine TMAO levels were highly correlated (Figure S1b), whereas the correlation between plasma and urine carnitine levels was modest and nonlinear (Figure S1c)

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, IL-6, IL-1, TNF-, and PGE2 )and serum lipopolysaccharides levels [216,217,218,219,220] and disrupting the intestinal environment, including reducing the diversity of intestinal microorganisms [216, 217] and fecal SCFAs [216, 217, 221], and regulating intestinal PH value [221] and oxidative stress through glycoxidation (NO, protein carbonyl (PCO), MPO and alkaline phosphatase (ALP)) [220, 221]

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