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26 Young users appear to rapidly develop a physical dependence from smokeless tobacco use and experience withdrawal symptoms after a relatively short time, as a regular user

Oncotarget 7 (30), 4687846889 (2016)

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In addition, it is important to inform the doctor if other quit-smoking drugs such as Aplenzin, Forfivo, Wellbutrin, Zyban, or Bupropion or any nicotine replacement therapies like nicotine gum, inhaler, lozenges, skin patches, or nasal spray are being used