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22, 1975, with the publication of the editorial entitled Cigarette smoking, coronary heart disease and sudden death ( Can Med Assoc J 113: 919, 1975), this Journal has recorded the proven and potential hazards of smoking-related to pulmonary carcinoma, chronic bronchitis, and emphysema to the smoker

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Participants were questioned about their exposure to smoking throughout their lives, and then their health was tracked over the next 22 years

Although we did not find an effect using multiple genome-wide significant genetic variants, we noted that one SNP (rs3804640) stood out in particular, showing a large positive effect of bipolar disorder on smoking initiation and lifetime smoking in the single SNP analysis (supplementary Figs 5, 11)