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Globally available over-the-counter 9 Included in: WHO policy recommendation and Model List of Essential Medicine since 2009 30-32 European Network for Smoking and Tobacco Prevention (ENSP) Tobacco Dependence Treatment Guidelines 33 NRT Combination Therapy is recommended by NICE as a first-line treatment option8 NRT single therapy is recommended by NICE as a second-line treatment option 8 Cytisine: Suitable for 18+18 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2024 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Under consultation to add as first line treatment option 8 Varenicline: Suitable for 18+ 19 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Varenicline is recommended by NICE as a first-line treatment option 8 Bupropion: Suitable for 18+20 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Bupropion is recommended by NICE as a second-line treatment option 8 To keep in mind: NRT Combination Therapy is one of the most effective ways to help your patient quit for good 8 Speed of action and cravings relief Observational field studies indicate that cue-induced cravings are substantially responsible for relapse to smoking 35

as a whole (based on observed consumption and smoking prevalence for the U.S.), the average smoker consumed 377.5 packs per year in 1995, and this volume has declined by nearly eight packs per year through 2006, as displayed in Figure 1.[] Given this close-to-linear trend in smoking intensity and the lack of data for this variable, we make some simplifying assumptions

"We just wanted to write down one pathway that the average clinician could use for a majority of their patients," he said.

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From cigarette smoke in vehicles to wildfire smoke in large properties, our solutions have been tested and proven effective in diverse scenarios