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Inhalation toxicity ADD TO CIGARETTES 482 ingredients: 460 flavors 1 flavor/solvent 1 solvent 7 preservatives 5 binders 5 humectants 1 filler 2 process aids (one is water) Mixtures added to US blended tobaccos 19 Test cigarettes in 3 series made 44 Hoffmann analytes determined Bioassays and inhalation CIGARETTE SERIES Series AFlavorings Series BFlavorings and casings Sheet ingredients Series CCasings Inhalation toxicity 90-day inhalation with rats Series A, B and C cigarettes no statistically-significant differences in the animals subjected to smoke from the test and control cigarettes In vitro bioassays on smoke particulate matter 1

Health experts say e-cigarettes need more stronger regulations to prevent youth access and use

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