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Excluding China, where the market is monopolised by the state, five major companies dominate the global tobacco trade Philip Morris International (PMI), British American Tobacco, Japan Tobacco, Imperial Brands and Altria (the former US assets of PMI)

For instance, glucuronidation, a phase II metabolic process catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, appears to be influenced by smoking, as evidenced by the findings related to atorvastatin metabolism

That worries antismoking advocates, who fear a reversal of the yearslong decline in U.S