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Low ADPN levels are correlated with obesity, hypertension, and diabetes [153], whereas elevated ADPN levels enhance glucose uptake and FAO via AMPK activation, improving insulin sensitivity

The issue lies in the fact that individuals without a carnitine deficiency, particularly vegans and vegetarians who are at risk, do not have low plasma levels of carnitine

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the gastrointestinal side effects and visible weight loss typical of this class threaten the integrity of trials with subjective outcomes, which again argues for objective endpoints