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The results consistently indicated that smokers achieved a lower plasma concentration of the drug compared to non-smokers at the same dose, or a lower concentration/dose (C/D) ratio in smokers [28, 43, 61, 70]
For the primary purpose of sedation and relief of anxiety, the usual recommended initial dose of lorazepam for intravenous injection is 2 mg total, or 0.02 mg/lb (0.044 mg/kg), whichever is smaller
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