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By 1910, James Buchanan Duke controlled Lorillard and the American Tobacco Company even as it kept its original name

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We characterized the impact of nAChR agonists on brain function using the ALE framework (paralleling that described above) and separately identified brain regions showing either convergent activity increases or decreases using a cluster-level corrected threshold ( p corrected 4000 compounds present in tobacco smoke [67], and/or be mediated directly or indirectly by nicotine itself

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