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Periorbital study (28 days) : Palmitoyl pentapeptide-4 cream (0.005%) applied twice daily to the periorbital area decreased fold depth by 18%, fold thickness by 37%, and improved skin firmness by 21%

NO plasma concentration was measured by the Griess reaction as NO 2 concentration after NO 3 reduction to NO 2 as currently performed in our laboratory [20]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Honda K., Komoda Y., Inoue S