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Cross-linking of surface IgE molecules results in exocytosis of preformed mediators such as amines and proteases, as well as release of newly generated mediators including leukotrienes, prostaglandins and a variety of cytokines [7]

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[3] To further investigate the link, the Medical Research Council (MRC) instructed its Statistical Research Unit (later the Oxford-based Clinical Trial Service Unit ) to conduct a prospective study into the link