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Genetic predisposition influences addiction risk in an individual by altering the normal functioning of their brains reward system after initial exposure to drugs

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The specific pain relievers that individuals misused in the past year were categorized into 11 subtypes (i.e., not counting other prescription pain relievers), such as hydrocodone products (Figure 31)

Very common side effects (affecting more than 1 in 10 people) include nausea, diarrhoea, vomiting, constipation, and decreased appetite

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