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[7] After injury, TB-500 seems to enhance the expression of IL-1 and IL-6 mRNA in murine model corneas

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This cascade activates caspase-8 and downstream caspase-3 (Takahashi et al., 1999), leading to DNA fragmentation and keratinocyte apoptosis (Simon et al., 2006)

And know that there may be (multi-colored) light at the end of the tunnel: "While there is no true permanent reversal of gray hair yet, there are promising studies on stem cells that focus on manipulating melanocytes and reactivating genetic pathways for hair melanin production, so we may see it become reality in the future," Wizemann says

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