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Incretin therapy is used either with GLP-1 receptor agonists or with inhibitors of DPP-4, which is the enzyme that inactivates endogenously released GLP-1
These medications work by: [1] stimulating insulin secretion slowing down gastric emptying (how quickly food leaves the stomach) reducing appetite and cravings slowing down the release of glucagon from the pancreas (a hormone that increases blood sugar when levels get too low)
Rapid weight loss can also obscure underlying disease
Higher oral doses cause loose stools, which is actually the mechanism behind magnesium-based laxatives
Ulasoglu C, Temiz HE, Salam ZA
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