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The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression

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These rings are connected by a seven-carbon chain that includes two carbonyl groups located at positions 3 and 5 (commonly referred to as the -diketone moiety), which can undergo keto-enol tautomerism [14] (Figure 1)

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