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Nicotine & Tobacco Research , 18 (5), 906-912

Replied 12/7/2020 (optional) Charles I remember Italian cigars as having a very distinctive aroma...talking approximately 40-50 years ago when my uncles smoked them...not the same anymore...tried Dinobli and Perodi and they just don't have that distinct aroma

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It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]