By activating GLP-1 receptors, these drugs enhance glucose-dependent insulin secretion from pancreatic -cells and suppress inappropriate glucagon release from -cells, thereby lowering blood glucose only when levels are elevated (reducing hypoglycemia risk)
Collectively, these data highlight an important role of ETC and mitochondrial lipid redox signaling in GPX4-dependent ferroptosis in AML cells and anticipate that targeting both pathways (i.e
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Sushovan Guha, MD, MA, PhD, FASGE, AGAF, is a Houston-based gastroenterologist and hepatologist at Houston Regional Gastroenterology Institute with extensive academic experience, specializing in general GI care, colorectal cancer prevention, and advanced endoscopic procedures.
In this context, the purpose of the present article is to review the status of the gliptins currently in clinical use, with special emphasis on their capabilities to positively or negatively affect the cardiovascular system, and their potential involvement in major adverse cardiovascular events (MACE)