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This study also identified the depletion of the purine metabolite, hypoxanthine, in chronic fatigue patients (according to Canadian Consensus criteria) which may impair ATP production and contribute to the biochemical changes associated with PEM
De-escalation strategies in HER2positive early breast cancer (EBC): final analysis of the WSG-ADAPT HER2+/HR- phase II trial: efficacy, safety, and predictive markers for 12 weeks of neoadjuvant dual blockade with trastuzumab and pertuzumab +/- weekly paclitaxel
Following the semi qualitative assessment, the ROS levels were quantified by flow cytometry
The specific metabolic benefit appears to result from gut bacteria modifications, increased Bifidobacterium and decreased Firmicutes species
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