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El principio activo semaglutida comercializada bajo las marcas Ozempic, Wegovy o Rybelsus y muchos otros, como tirzepatida (Mounjaro), liraglutida (Victoza o Saxenda) y dulaglutida (Trulicity), nacieron en el mbito del tratamiento de la diabetes, pero han saltado a la fama por su efecto sobre el apetito y el peso

Weight loss under the action of GLP-1RA is not only caused by acting on the hypothalamus or parasympathetic nervous system, thereby inhibiting appetite and delaying gastric emptying, but also by acting on white and brown adipocytes

This limitation is particularly critical for East African countries, where agriculture and hydropower generation depend heavily on rainfall, making societies highly vulnerable to variability and extremes

In a highdose semaglutide trial (7.2 mg weekly), participants lost about 20.7% of body weight in 72 weeks, with a substantial portion achieving up to 25% weight loss

Preventing injection site reactions Injection site reactions (redness, swelling) are very uncommon with semaglutide