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Growing body of evidence suggests that dysfunction of the GLP-1 pathway, which directly targets mitochondria and preserves mitochondrial functions, contributes to the pathophysiology of depression [86]

These typically include: Erythema (redness) at the injection site Pruritus (itching) localised to the area Swelling or induration (hardening of tissue) Mild pain or tenderness Bruising (ecchymosis) in some cases These reactions usually appear within hours to days following injection and typically resolve spontaneously within 25 days without specific intervention

In Wegovy trials, hair loss was reported by about 2.5-3% of users versus about 1% on placebo, and it shows up more with larger weight loss