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S-Nitrosoglutathione and glutathione act as NMDA receptor agonists in cultured hippocampal neurons

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Under physiological conditions, more than 98% of the total GSH pool exists in the reduced form, thereby shaping cellular redox potential and influencing proliferation, differentiation, and cell death 5 .Although the GSH/GSSG ratio has long been regarded as an indicator of cellular redox status, recent live-cell studies using genetically encoded redox sensors indicate that increases in GSSG are typically transient and compartmentalized rather than sustained intracellular accumulations 6,7

Cleft lip and palate versus cleft lip only: are they distinct defects