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Such effects on the brain include: Anxiety Confusion Decreased coordination Depression Disorientation The feeling of being lost Suicidal thoughts A study in PLOS One found a significantly flat affect in long-term Suboxone patients, noting they had less self-awareness of being happy, sad and anxious, compared to the general population or Alcoholics Anonymous (AA) groups

Increased fatigue and tiredness

National Academies of Sciences, Engineering, and Medicine (Washington, DC: National Academies Press)