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Potential Negative Effects on Mental Health While the potential benefits are encouraging, its crucial to acknowledge the potential negative impacts of GLP-1 inhibitors on mental health: Increased Anxiety and Agitation: Paradoxically, while some studies suggest anxiety reduction, others have reported instances of increased anxiety, restlessness, and agitation in individuals taking GLP-1 agonists

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For example, a patient on the 15 mg maintenance dose could step down to 10 mg, then 7.5 mg, then 5 mg, and finally 2.5 mg before complete discontinuation

In an early Phase 2 trial, patients lost on average 24 percent of their weight, the highest of any obesity drug so far