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Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

The total rates of gastrointestinal adverse events were 39%, 46%, and 49% for the 5mg, 10mg, and 15mg doses, respectively

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Overexpression of pS6, mTOR activation, calcitonin, and C-cell hyperplasia reported in in vivo suggest the increased proliferation and tumorigenesis [75, 87]