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As more of the nicotine is absorbed by the body in high-dose exposure, symptoms transition to lethargy, depression, low blood pressure, normal or elevated heart rate, paralysis, respiratory depression or arrest, and death

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Evidence-based quit strategies include: Nicotine replacement therapy (NRT): Patches, gum, lozenges, inhalers, and nasal sprays provide controlled doses of nicotine to ease withdrawal without the harmful chemicals in smoke