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Traditional tobacco cigarette smokers had strikingly higher odds of having a heart attack, coronary artery disease and stroke compared with nonsmokersa 165, 94 and 78 percent increase, respectively

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That would make sense if it's compacting too much in the middle, Though I don't notice it if the tobacco is just at the right RH

The toxic substances found in tobacco smoke damage the airways and lung tissues, leading to chronic obstructive pulmonary disease (COPD), emphysema and chronic bronchitis