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Some of them are histamine (contributes to pain and itching, and can also be an allergen), serotonin (contributes to the pain, it is an irritant), noradrenaline (responsible of the constriction of the blood vessels, which results on a blood pressure increase)
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The protective effect was also correlated with greater duration and frequency of smoking.[] Similarly, in a large cohort study that followed 1, 59, 340 women over a 12.7 years period, the authors found that current smokers had reduced risk for all types of thyroid cancer
Funding This work was supported by Shanxi Basic Research Program (Free Exploration Category) Natural Science Research Project (Number:202203021211067);2025 Annual "Promising Candidates" Cultivation Project for National Natural Science Foundation at Shanxi Bethune Hospital (Number:2024GZRZ07)