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In liver cancer models, MYC-driven metabolic reprogramming precedes tumorigenesis, with early-stage premalignant hepatocytes favoring pyruvate-to-alanine conversion, whereas later-stage malignant lesions preferentially convert pyruvate to lactate [213]

There is a clear public health implication here, suggesting that smoking cannabis with tobacco does not improve the subjective effects of cannabis, and makes it more harmful to one's physical health

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