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Common physical symptoms include: Dilated pupils that remain enlarged even in bright light conditions Rapid and significant weight loss caused by appetite suppression Chronic insomnia and irregular sleep patterns despite exhaustion Elevated heart rate and persistently high blood pressure Excessive sweating unrelated to heat or physical activity Teeth grinding (bruxism) and jaw clenching, particularly common with MDMA and meth Dental deterioration known as meth mouth in long-term methamphetamine users Nosebleeds, nasal damage, and chronic congestion in cocaine users Psychological and Cognitive Symptoms The psychological toll of stimulant addiction is often the most debilitating aspect of the disorder

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The risks of 29 CVD subtypes were significantly elevated in current compared to never smokers in our study, contributing evidence that few, if any parts of the cardiovascular system remain untouched by smoking, as measured by the occurrence of disease serious enough to cause hospitalisation or death

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