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This medication is not suitable for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

This makes the vials an ideal option for people without insurance (or for those who don't have insurance coverage for Zepbound)

Hypokalemia can also lead to irregular heart rhythms, which can be dangerous

This may reflect the gradual dose escalation with weekly dosing that allows adaptation to GI side effects

The 25 to 30 day washout is the minimum for safe transition, and extending it slightly for those on higher tirzepatide doses is prudent risk management