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In genetically susceptible individuals, this chronic immune activation can initiate or worsen autoimmune responses against distant tissues

Fatigue affects roughly 13% of participants, particularly during the early weeks when caloric intake drops significantly

Age over 50, male sex, and South Asian ethnicity represent demographic factors associated with higher prevalence

A more recent systematic review and meta-analysis published in BMJ Nutrition, Prevention & Health (2024) suggested that ACV consumption was associated with modest reductions in weight and blood glucose levels

Perrone M, Patergnani S, Di Mambro T, Palumbo L, Wieckowski MR, Giorgi C, et al