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Mutations in the AIRE gene cause autoimmune polyendocrinopathy, a condition where multiple organs come under immune attack simultaneously

Zhang T, Liu J, Shen S, Tong Q, Ma X, Lin L

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ALC treatment increases DA and 5-HT release and receptor activity while decreasing the 5-hydroxyindoleacetic acid (5-HIAA)/5-HT ratio, the latter representing lower 5-HT turnover (Sarzi-Puttini et al

Meanwhile, DTIC did affect the kinetic and thermodynamic interactions of the CD44 ligandreceptor, presenting greater dissociation rate, lower affinity, lower binding free energy, and a narrower energy valley for the free-energy landscape