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Common Side Effects: Gastrointestinal Issues: Nausea, vomiting, diarrhea, constipation, and abdominal pain are the most frequently reported

As such, rotenone can either increase or decrease mitochondrial ROS production at complex 1, depending on whether glutamate-malate (forward) or succinate (reverse) are provided as respiratory-chain substrates, respectively

: L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain Gustavo C Ferreira et al

Pregnancy and breastfeeding are also important safety areas