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(2013) characterized the role of NNMT in cancer cell metabolism, demonstrating that NNMT activity creates a metabolic sink for SAM

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Unlike endogenous cannabinoids, THC also increases mitochondrial hydrogen peroxide production [39], and reactive oxygen species (ROS) production and neuronal apoptosis in mPFC [32], a brain region critically involved in neuropsychiatric pathology

On the drug pricing front, the Trump administration brokered most-favored-nation (MFN) pricing deals with Novo Nordisk and Eli Lilly in November 2025, reducing GLP-1 prices for Medicare/Medicaid to approximately $245/month and launching a direct-to-consumer platform (TrumpRx) offering prices around $350/month ( [17] )