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In addition, MPO secreted by TANs can catalyze the production of hypochlorous acid (HOCl) from H 2 O 2 and Cl, which directly oxidizes tumor cell membrane lipids, resulting in a 4-fold increase in lipid peroxidation and accelerating the ferroptosis process

4 Folate (vitamin B9) deficiency is also common in those with MTHFR

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Damaged hepatocytes release ROS into the extracellular environment, thereby activating ROS-generating hepatic stellate cells

Crosstalk between depression and breast cancer via hepatic epoxide metabolism: A central comorbidity mechanism