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In fact, the Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk concluded in 2009 that the association between active smoking and breast cancer is consistent with causality. In other words, evidence strongly suggests that tobacco smoke causes breast cancer, although further study is needed to fully understand howand whether the connection also holds true for vaping, cannabis, and secondhand smoke

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However, in human sperm, around 15% of the DNA is still bound by histones in locations unique to certain sequences, suggesting a particular program of gene expression following fertilization [53, 54]

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