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Hcy also exerts a pro-inflammatory effect on endothelial cells (ECs), inducing the secretion of pro-inflammatory cytokines (IL-1, IL-6, IL-8, and TNF-)

Nieswandt, B., Varga-Szabo, D

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Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig