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In clinical trials, the half-life of cagrilintide (0.164.5 mg) ranged from 159 to 195 hours, and the elimination half-life ranged from 7 to 8 days, making cagrilintide suitable for once-weekly dosing

Importantly, folic acid should not be given alone before B12 deficiency is excluded or treated, as this can mask anaemia while allowing neurological damage to progress

Many patients with tingling or numbness begin to notice a reduction over months two and three, with further recovery beyond six months

Vitamin B12 is unique among the B vitamins because it is not found in plant-based foods in significant amounts