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Women using tirzepatide with oral contraceptives should use non-oral contraception or add a barrier method for 4 weeks after initiation and after each dose increase

This is changing in real time as we learn more and more about Tirzepatide, though

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Understanding how each one works at the receptor level explains why their outcomes diverge so dramatically in clinical trials and why choosing between them requires more than just comparing weight loss percentages

8 , 14 However, since 2020, increased public awareness of GLP-1 RAs for diabetes, weight loss, and cardiovascular disease prevention has led to a surge in their use