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This is supported by the evidence that human skin pigmentation has evolved in parallel to our UVR environment, as a likely mechanism to maintain a balanced biological influence of UVR, irrespective of latitude

Notably, it has been reported that 88% of the human peripheral blood monocyte population is positive for ER (using a monoclonal antibody that recognizes both isoforms), providing direct evidence for ER expression in a key immune cell subset and supporting estrogens modulatory role in monocyte function

Wang X, Shen T, Lian J, et al

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It is regarded as food for the brain and involved in energy production