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This article examines the side effect profile of B12 therapy in older adults, covering common reactions such as injection site discomfort and gastrointestinal symptoms, rare serious adverse events requiring urgent medical attention, important drug interactions with medications like proton pump inhibitors and metformin, and evidence-based dosing guidance aligned with NICE and BNF recommendations for safe, effective B12 replacement in this vulnerable population

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This figure is directly comparable to the performance of tirzepatide (Mounjaro) in the SURMOUNT-1 trial, which showed approximately 20.9% weight loss at 72 weeks, and exceeds the approximately 14.9% achieved by semaglutide alone in STEP 1

Int J Mol Sci (2019) 20(8):193558