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The results show that hyperalgesia (increased mechanosensitivity and thermosensitivity) was induced from 3 to 7 weeks after methylmercury exposure, followed by hypoalgesia (decreased mechanosensitivity and thermosensitivity) from 13 to 15 weeks after exposure

Therefore, inhibitors combination against these antioxidant systems with such prooxidant properties is required to elevate the intracellular ROS concentrations within tumor cells and it may be crucial to devastate the antioxidant systems beyond the threshold of toxicity level

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