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As Mark Hyman, M.D., writes in a post on his blog titled Essential Glutathione: The Mother of All Antioxidants, poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete the bodys GSH stores (3)

Recently, single-cell (sc) RNA sequence (RNA-seq) analyses of immune cells from brain samples of an AD model (5XFAD) identified microglial clusters named disease-associated microglia (DAM), which appear under neurodegenerative conditions 21

Beginners should start at 250 mcg daily to assess individual tolerance and response before potentially increasing the dose