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La hiperglicemia eleva paradjicamente la secrecin de glucagn, el cual aumenta la produccin heptica de glucosa y agrava la hiperglicemia ya que agrega glucosa endgena a la ingerida, especialmente en el periodo postprandial

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Damage to the tubular endothelial cells can increase leukocyte adhesion, platelet aggregation, and vasoconstriction, reduce blood flow to nephrons, and damage the glomerular barrier and the extensive network of peritubular capillaries (88)

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